A reflex is an involuntary, predictable, and specific response to a stimulus dependent on an intact reflex arc. A stimulus that is strong may produce irradiation of cutaneous signals with activation of protective withdrawal reflexes. The superficial reflexes of the upper extremities are palmar reflex, scapular or interscapular reflex, and superficial abdominal reflexes. The superficial reflexes of the lower extremities include cremasteric reflex, gluteal reflex, plantar reflex, and superficial anal reflex. The deep tendon reflex (DTR) results from stimulation of the stretch-sensitive IA afferents of the neuromuscular spindle producing muscle contraction via a monosynaptic pathway. Abnormalities of the deep tendon reflexes, examination of primitive and tonic reflexes, pathologic reflexes, pathologic reflexes in the lower extremities, postural and righting reflexes in infancy and childhood, physiologic associated movements, pathologic associated movements, and coordination examination are the other important topics which are also discussed thoroughly in this chapter.