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Chapter-03 Disorders of Platelets and Coagulation Factors

BOOK TITLE: Hematopathology Pearls

Author
1. Zhang Da
ISBN
9789352703234
DOI
10.5005/jp/books/14222_4
Edition
2/e
Publishing Year
2018
Pages
18
Author Affiliations
1. The University of Kansas School of Medicine, Kansas City, Kansas, USA, University of Kansas Medical Center, Kansas City, Kansas, USA, University of Kansas Medical Center, Kansas City, Kansas 66160, USA, University of Kansas Medical Center Kansas City, Kansas 66160, USA
Chapter keywords
Platelet, coagulation factor, hepatocyte, endothelial cell, vitamin K, coagulation test, fibrinolytic system, acquired coagulation disorder, anticoagulant therapy

Abstract

This chapter discusses disorders of platelets and coagulation factors. All coagulation factors are made by hepatocytes in the liver, except for Factor VIII, which is made by endothelial cells in the liver. The half-lives of these coagulation factors are variable, ranging from 6 hours (Factor VII) to 5 days (Fibrinogen). The synthesis of these coagulation factors depends on the availability of vitamin K. The vitamin K-dependent coagulation zymogens are precursors of serine proteases that must be proteolytically activated to express their enzymatic activity. This chapter covers the coagulation tests, the natural inhibitors of coagulation, fibrinolytic system, inherited coagulation disorders, acquired coagulation disorders, platelets and von willebrand factor, and hereditary thrombotic disorders and anticoagulant therapy monitoring.

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