A posterior vitreous detachment (PVD) is defined as a separation of posterior vitreous cortex from the inner retinal membrane. Posterior vitreous detachment presents the physiological condition in elderly. However, it can appear in patients with high myopia, due to increased axial length of the eye, as well as postoperatively or after traumatic injuries and inflammations of eyes. PVD occurs due to the aging, liquefaction, and syneresis of the vitreous, which results with pathological changes in area of vitreoretinal junction. Differential diagnosis includes retinal detachment, retinal holes, ocular migraine, and intraocular inflammations (uveitis). If PVD without complications occurs, treatment is not advised. Regular ophthalmology control examinations are enough. There is no recommended therapy for PVD.