Toxoplasmic chorioretinitis is an inflammation of the retina and choroid which is caused by the intracellular parasite Toxoplasma gondii. Toxoplasma gondii is the intracellular parasite and most common cause of posterior uveitis in developed Western countries. It is the second leading cause of the infective chorioretinitis in immunocompromised patients (the first cause is cytomegalovirus). The disease, in most of patients, occurs due to the acquired acute or recurrent infection by the parasite. Differential diagnosis includes macular scar, cat-scratch disease, ocular sarcoidosis or tuberculosis, and progressive ocular necrosis of the outer retinal layer caused by aspergillus, candida, or as a complication of syphilis. The diagnosis is based on anamnesis, clinical examination and serological tests.