This chapter describes about the central sterile supply department that caters to the requirements of the entire institute. Strips of heat sensitive tape also do monitoring, which are applied externally and internally. The main operation theater set and trays for invasive procedures containing Bacillus stearothermophilus spores are autoclaved keeping them in most unreachable part of the autoclave chamber. These are then cultured to see, whether all the spores have been destroyed. Verification of sterility assures that the parameters of a validated sterilization process are consistent with what is expected and repeatable.