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Chapter-02 Etiology and Diagnosis of Premature Ovarian Insufficiency

BOOK TITLE: Manual of Clinical Dilemma in Mature Women

Author
1. Lumsden Mary Ann
ISBN
9789352703739
DOI
10.5005/jp/books/18026_3
Edition
1/e
Publishing Year
2018
Pages
5
Author Affiliations
1. School of Medicine, University of Glasgow, Scotland, UK, University of Glasgow, UK; International Menopause Society, UK; Royal College of Obstetricians and Gynaecologists (RCOG), UK
Chapter keywords
Premature ovarian insufficiency, POI, follicle-stimulating hormone, FSH, premature ovarian failure, POF, luteinizing hormone, LH, genetic, iatrogenic, autoimmune disorder

Abstract

Premature ovarian insufficiency (POI) is defined as amenorrhea for 6 months and is associated with elevated follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels due to failure of the ovaries. Early menopause is when this occurs in women under 45 years of age. The term POI is used rather than premature ovarian failure (POF) as resumption of function occurs in a small proportion of women. The exception to this is if the ovaries are absent or removed surgically. This chapter describes the etiology and diagnosis of POI. The etiology includes following as genetic, iatrogenic, autoimmune disorders, and environmental toxins.

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