Polycystic ovary syndrome (PCOS) is a lifelong disease. It is a challenge to distinguish menopausal changes from abnormalities connected with PCOS. The expression of PCOS may begin early and the symptoms change across the lifespan. Determining the appearance and expression of the syndrome at each stage of life will be important to expand the diagnosis and treatment of PCOS. Polycystic ovary syndrome in postmenopausal women is not well-defined as there are no robust criteria. Older women with PCOS still had lower levels of sex hormone binding globulin (SHBG). Postmenopausal women with PCOS are exposed to higher adrenal and ovarian androgen levels than non-PCOS women. The metabolic features are primarily related to underlying insulin resistance (IR), which is now understood to play an important role in both the pathogenesis and long-term sequelae of PCOS.