Disseminated intravascular coagulation (DIC) is characterized by systemic activation of blood coagulation system characterized by microvascular thrombi formation in various organs which can cause multiorgan failure. Consumption causes exhaustion of coagulation proteins and platelets, inducing severe bleeding complications. The prevalence of DIC in pregnancy ranges from 0.03–0.35% in population-based studies, or 12.5 per 10,000 delivery hospitalizations in one study. This chapter covers the normal coagulation cascade, physiological changes in pregnancy, triggering factors for DIC, etiology, mechanism of DIC in different obstetric conditions, symptoms, and management.