Jaundice in pregnancy can result either because of conditions specific to pregnancy or because of causes which can occur in the general population. It is important to correctly diagnose the etiology, as different causes have different maternal and fetal outcomes and the management also differs. The clinical picture, mainly nonhepatic manifestations along with biochemical evaluation, may help in arriving at a diagnosis; however, sometimes the clinical picture may be confusing and difficult to diagnose correctly. This chapter covers the obstetric cholestasis, acute fatty liver of pregnancy, and viral hepatitis in pregnancy along with their etiology, clinical feature, and management. Acute fatty liver of pregnancy (AFLP) was also previously called acute yellow atrophy of liver. AFLP is a rare life-threatening complication of pregnancy that occurs in the third trimester or the immediate period after delivery.