Chapter-12 Oral Antihyperglycemic Drugs in Pregnancy: A Review

BOOK TITLE: Clinical Guidelines for Management of Diabetes in Pregnancy

1. Aggarwal Ramesh
2. Jain Sachin K
3. Srivastava Anshuman
Publishing Year
Author Affiliations
1. Lady Hardinge Medical College and SK Hospital, New Delhi, India, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
2. Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
3. Lady Hardinge Medical College, New Delhi, India
Chapter keywords
Diabetes mellitus, DM, gestational diabetes mellitus, GDM, oral antihyperglycemic drug, OAHD, pregnancy, metabolic disorder, medical nutrition therapy, MNT, randomized controlled trial, RCT, insulin therapy


Diabetes is one of the most common metabolic disorders that complicate pregnancy. The prevalence of overt diabetes mellitus (DM) and gestational diabetes mellitus (GDM) has risen globally. Approximately 90% of diabetes in pregnant women is attributed to GDM. Insulin has been the gold standard therapy for DM and GDM. However, insulin therapy can be inconvenient as it requires multiple daily injections, has a high cost, and requires refrigerator for storage, which results in poor patient compliance. There is a growing interest for the use of oral antihyperglycemic drugs (OAHD) in GDM and overt DM2 in pregnancy. Oral antidiabetic agents (OAHDs) have been used and are being studied whether they can also be used as an alternative to insulin therapy because of their ease of use and lower cost. This chapter covers the current position of oral antihyperglycemic drugs in the management of diabetes in pregnancy and treatment of gestational diabetes mellitus by oral antihyperglycemic drugs.

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