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Chapter-27 Fertility Issues with Hyperglycemia

BOOK TITLE: Clinical Guidelines for Management of Diabetes in Pregnancy

Author
1. Malik Sonia
2. Chhabra Neeti
ISBN
9789352703951
DOI
10.5005/jp/books/18049_28
Edition
1/e
Publishing Year
2018
Pages
16
Author Affiliations
1. CGHS, Chandigarh, India, Holy Angels Hospital, New Delhi, India, Southend Fertility and IVF Centre, Holy Angels Hospital, Delhi, Southend Rotunda Center for Human Reproduction, Holy Angels Hospital, Vasant Lok, Vasant Vihar, New Delhi, India, Southend Rotunda, Center for Human Reproduction, Holy Angels Hospital, Vasant Vihar, New Delhi, National Institute of Communicable diseases, New Delhi, India, Southend-Rotunda Center for Human Reproduction, Holy Angels Hospital, New Delhi, India, Southend Fertility and IVF Centre, Holy Angels Hospital, Vasant Lok, Vasant Vihar, New Delhi, India, E-mail: sm_doc@rediffmail.com; sm_doc@hotmail.com, Southend Rotunda (Centre for Human Reproduction), Holy Angels Hospital, Vasant Vihar New Delhi, Southend Fertility and IVF Center, Holy Angels Hospital, Vasant Vihar, New Delhi, India, Southend Fertility and IVF Center, Holy Angels Hospital, New Delhi, India, Southend Fertility and IVF Center, New Delhi, India, Southend Fertility and IVF Centre, New Delhi, India, Southend Fertili
2. Army Hospital (Research and Referral) New Delhi, India, Southend IVF, New Delhi, India, Southend Fertility and IVF, Delhi NCR, India
Chapter keywords
Infertility, hypoglycemia, hyperglycemia, oral hypoglycemic agent, pharmacotherapy, metformin, inositols, blood vessel, diabetes

Abstract

Infertility is defined as the inability to conceive after 1 year of regular unprotected intercourse. The incidence of infertility is on the rise. Diabetes mellitus is a metabolic disorder. It mainly involves abnormality of carbohydrate metabolism. The disease process is multipronged and has widespread ramifications. It involves vital organs such as eyes, nerves, kidneys, liver, blood vessels, and reproductive tissues as well. Type 1 diabetics are genetically predisposed and it gets activated by the environmental factors. Hyperglycemia and diabetes are implicated as causative and contributory factors in the development of subfertility and infertility in both men and women. This chapter covers the risk factors common for infertility and hyperglycemia, diagnosis, management, and oral hypoglycemic agents. Management of diabetes involves a holistic approach which includes lifestyle management and pharmacotherapy. The two most important drugs implicated in the treatment of PCOS are metformin and inositols. Metformin and inositols improve oocyte quality in infertile PCO patients and convert anovulatory cycles to ovulatory.

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