Locomotion is the progressive movement of the entire body from one place to another, by means of self-propulsion. Usually this propulsion is provided by the lower limbs, but sometimes this may involve all four limbs or very rarely, with the upper limbs alone. The locomotion in humans includes all activities in which the entire body is moved by the action of its levers with the assistance of gravitational force. The essential feature in all locomotion is the movement of entire body from the point of contact between body part and the supporting surface. For this, some body part must apply force to the surface, and the surface must resist that applied force. Human locomotion is an interaction of body’s neurologic, musculoskeletal and cardiopulmonary systems. Locomotion may be on the ground or in the water (swimming), but the most common forms of locomotion which occur on the ground are—walking and running, both are discussed in detail in this chapter.