Infertility is defined as the inability to conceive after 1 year of regular unprotected intercourse. A diagnosis of unexplained infertility is given, when the results of standard infertility evaluation are normal. The prevalence of unexplained infertility ranges from 8–37%. Subfertility is a better term for unexplained infertility because many of them will conceive without any intervention within next 2–3 years. This chapter covers the infertility evaluation, assessment of male infertility, assessment of ovulation, assessment of uterus and fallopian tubes, assessment of ovarian reserve, ultrasound, sonohysterography, the role of laparoscopy, and management. The management of unexplained infertility remains debatable chiefly due to couple’s impatience to complete planned protocols, lack of strong evidence and dominance of assisted reproductive technology (ART) treatment compared to other options in infertility clinics. Unexplained infertility needs individualized treatment, which is decided after considering the age, duration of infertility, treatment history, costs, risks, couples’ preferences, and the healthcare setting. Such couples need psychological support and good counseling.