Recurrent pregnancy loss (RPL) is an important health issue affecting 2–5% couples, whereas the incidence of infertility in the general population varies from 10% to 15%. Infertility and RPL are considered mutually exclusive entities, evaluated and managed by caregivers across various facilities. Infertility is defined as the inability to conceive after 12 months or more of unprotected intercourse, while RPL is ambivalently characterized by a history of 2 or 3 clinically documented pregnancy loss. Luteal phase defects are known to cause RPLs as well as infertility. Traditionally, progesterone supplementation in the luteal phase has been recommended due to its immunomodulatory and uterine relaxation action. Advanced maternal and paternal age have an effect on both infertility as well as RPL. Lifestyle modifications should be implemented to improve reproductive outcome as almost half of the cases of RPL and almost 10% cases of infertility are unexplained.