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Chapter-12 Pharmacology Charts

BOOK TITLE: Second MBBS Buster Pharmacology

Author
1. Layek Avishek
2. Rano Dyuti Deepta
ISBN
9789352704897
DOI
10.5005/jp/books/18063_13
Edition
1/e
Publishing Year
2018
Pages
10
Author Affiliations
1. Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India
2. Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India
Chapter keywords
Pharmacology chart, log dose-response curve, plasma concentration, time curve, kymographic tracing, compartment model, noncompartment model, physiological model

Abstract

This chapter seeks to familiarize the readers with pharmacology charts. There are three types of charts described here, i.e. log dose-response curves, plasma concentration versus time curves, and kymographic tracings. The dose-response curve is a simple X-Y graph relating the magnitude of a stressor to the response of a receptor. The response may be physiological or biochemical or even death. Plotting graded response produces sigmoid shaped curves whereas all-or-none responses produce quantal or bell shaped curves. Shapes of plasma concentration versus time curves depend upon the route of administration of the drug. Plasma concentration is plotted in Y-axis and time in X-axis. Types of pharmacokinetic models are compartment models, noncompartment models and physiological models. A kymograph is a device that draws a graphical representation of spatial position over time. Basically, it consists of a revolving drum wrapped with a sheet of paper on which a stylus moves back and forth, thus recording perceived changes of the phenomenon under observation. Questions related to these charts along with their answers are also covered in this chapter.

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