The objective of this chapter is to introduce the connective tissue and skeletal system. Connective tissue supports binds and protects the special (well differentiated) tissues of the body. It has both cellular and extracellular components. Types of connective tissue are loose connective tissue, dense connective tissue, ligaments, adipose tissue, pigmented connective tissue, and mucoid tissue. Skeletal system forms the general framework of the body. It bears weight without bending and has considerable tensile strength. It consists of cartilage and bone. Bone is a hard type of connective tissue which is highly vascular, living, changing minerals and having a low metabolic rate. Apart from its mechanical function, it is a storehouse for calcium. A joint is formed where two or more bones come together whether or not there is movement between them. The joints can be classified as follows according to the tissues that unite the bone ends—fibrous, cartilaginous and synovial joints. In this chapter, long essay type and short essay type questions are also provided.