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BOOK TITLE: Principles and Practice of Assisted Reproductive Technology
This chapter seeks to familiarize the readers with empty follicle syndrome (EFS). Empty follicle syndrome is a condition where no oocytes are retrieved despite repeated aspiration and flushing, after an apparently adequate ovarian response to stimulation, evidenced by serial ultrasound and adequate steroidogenesis. Due to uncertainty of its existence and variability in the inclusion criteria across different studies, its prevalence varies over a wide range, from as low as 0.045% to 7% of in vitro fertilization (IVF) cycles. Risk factors for early follicle syndrome, diagnosis and prevention of EFS, management of EFS in the current cycle, and management of subsequent cycles after EFS are the important topics which are covered throughout this chapter.