Pap smear, Visual inspection of cervix and colposcopy together are effective measures to diagnose precancerous lesions of cervix. This should be given importance in medical college education and more and more clinics giving this service must come up everywhere. In this chapter the author explains how to organize an early detection clinic. Methodology of taking adequate pap smear, instrumentation needed, method of fixation and transportation is explained. Colposcopic training, procedure and documentation is given with tips on how to start your own cytology and colposcopy clinic.