TORCH infections are a group of congenital infections which include Toxoplasma gondii (T), Rubella (R), Cytomegalovirus (C), Herpes Simplex Virus (H) and others (O-varicella zoster VZV, human immunodeficiency virus HIV, etc.). The incidence varies geographically and socieconomically. Fetal infection has been reported to occur in up to 10% of pregnancies per year. In the acute (viremic or parasitemic) stage of maternal infection, placental infection is initiated and subsequently fetal infection occurs. Any infection that occurs in the first 20 weeks of pregnancy can lead to spontaneous abortion due to direct placental damage, endometrial vascular involvement, primary embryonic death or may alter embryogenesis, with resultant congenital malformations (congenital rubella). If the infection occurs between 20 and 37 weeks, it can cause preterm labor and delivery. Infections acquired during the birth process result in neonatal morbidity. The classic “clinical triad” of TORCH baby refers to jaundice, petechiae and hepatosplenomegaly. Serological tests are used to diagnose acute infection in pregnant woman, which must be confirmed at a reference laboratory before abortion or treatment with potentially toxic drugs. Sporadic miscarriage is so common that detailed infective screening cannot be justified economically. TORCH screening should be abandoned in the investigative workup of recurrent miscarriages. Pregnancies complicated by possible maternal infection should preferably be referred to regional fetomaternal medicine centers. Infants with the suspicion of congenital infection and those born preterm, where infection may have played a role, need neurological follow-up by a competent pediatrician.