Amputations of the hand may occur as a result of trauma, or as an elective operation for malignant tumor or rarely in congenital deficiency. The main objectives of amputation are to preserve as much function as possible in injured and uninjured parts of the hand, shorten healing time and early return to work. One must examine the injured digit carefully and if there is damage of four out of six structures, namely skin, blood vessels, nerves, tendons, bones and joints, then one should consider amputation. Functions of the hand, apart from sensory perception, fall logically into three basic types i.e. precision manipulations, power grasp and nonprehensile functions. The fingertips are very important for sensory and manipulative functions. Fingertip ampuations can be classified based on the zone and plane of injury. The treatment of fingertip amputations vary markedly depending on amount of skin loss, the depth of soft tissue defect and whether the phalanx has been exposed or not. A brief discussion on amputations of single finger, critical points for finger amputation, ray amputations, amputation through the thumb and amputations of multiple digits have been provided in this chapter.