This chapter describes the rehabilitation of adult upper limb amputee. Postoperative therapy program, preprosthetic therapy program, determining the prosthetic prescription, fabrication and training time and adult upper limb prosthetic training are the steps for rehabilitation of adult upper limb amputee. Promote wound healing, control incisional and phantom pain, maintain joint range of motion, muscle strengthening and obtain adequate financial sponsorship are the goals of the postoperative therapy program. Presurgical management, postsurgical management, pregait training and gait training skill are the necessary for rehabilitation of adult lower limb amputee. The child amputee is also discussed in this chapter.