This chapter discusses crush syndrome. Crush syndrome is a condition in which rhabdomyolysis develops rapidly after the skeletal muscles are released from prolonged pressure, resulting in shock, acute renal failure, and other systemic symptoms. Majority of reported crush syndrome cases are associated with disasters involving collapse of heavy masses. Clinical features, laboratory evaluation, and treatments are also discussed in this chapter. Fluid therapy is the first choice in the management of crush syndrome because the development of shock and acute renal failure can be avoided by the early provision of fluid resuscitation. Hemodialysis in crush syndrome is important in treating acute renal failure and elimination of myoglobin. Fluid and electrolyte maintenance remains the mainstay of treatment.