This chapter discusses rheumatoid arthritis: etiopathogenesis, clinical features, and management. Rheumatoid arthritis (RA) is a chronic systemic autoimmune inflammatory disease, characterized by destructive symmetrical polyarthritis, affecting small joints of hand and foot, leading to radiological erosions and gradual deformities of joints. Genes play a key role in susceptibility to RA and disease severity. Clinical features of rheumatoid arthritis are onset, and joint involvement is briefly discussed in this chapter. The ankle involvement is usually mild in RA but damage can occur in severe progressive forms of the disease. Extra-Articular Manifestations, diagnosis, management, courses of disease, recent advances of course and treatments are also discussed in this chapter. Common drugs used are methotrexate (MTX), hydroxychloroquine (HCQ), sulfasalazine (SSZ) and leflunomide (LEF).