This chapter discusses current status of megaprostheses in limb salvage. Limb salvage surgery has revolutionized the management of patients with musculoskeletal tumors. The aim of limb salvage in bone tumor management is to eradicate the disease, retain the structural stability of the skeletal system and preserve a limb with useful function. Megaprostheses are defined as special segmental bone and joint endoprosthesis, which bridge large defects of joint and bones. The term “Megaprosthesis” was used first in the International Workshop on Design and Application of Tumor Prosthesis held at Mayo clinic in 1981. Megaprostheses provide an immediate return to function and are not affected by ongoing adjuvant treatment like chemotherapy and radiotherapy.