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Chapter-06 Vesiculobullous Disorders

BOOK TITLE: IADVL Color Atlas of Dermatopathology

Author
1. Khopkar Uday
2. Dongre Atul M
3. Mahajan Pradeep
4. Lee Nathan
5. Gardner Jerad
6. Ghate Smita
7. Buraik Mohamad
8. Gopinath Nandakumar
ISBN
9789385891236
DOI
10.5005/jp/books/12981_7
Edition
1/e
Publishing Year
2017
Pages
32
Author Affiliations
1. Seth GS Medical College and King Edward Memorial Hospital, Mumbai, India, KEM Hospital and Seth GS Medical, College, Mumbai, Maharashtra, India, KEM Hospital and Seth GS Medical College Mumbai, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India, e-mail: drkhopkar@gmail.com, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India, drkhopkar@gmail.com, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India, KEM Hospital and SGS Medical College, Mumbai, Maharashtra, India
2. Seth GS Medical College and KEM Hospital, Parel, Mumbai, Maharashtra, India, King Edward Memorial (KEM) Hospital and Seth Gordhandas Sunderdas Medical College (GSMC) Mumbai, Maharashtra, India
3. Dr Mahajan’s Dermatology and Dermatopathology Services, Pune, Maharashtra, India
4. University of Arkansas for Medical Sciences, Arkansas, USA
5. University of Arkansas for Medical Sciences, Arkansas, USA
7. King Fahd Hospital, Jazan, Saudi Arabia
8. Government Medical College, Thiruvananthapuram, Kerala, India
Chapter keywords
Vesiculobullous disorder, subcorneal-intraepidermal blister, suprabasal blister, subepidermal blister, eosinophils, neutrophils, acantholysis, bullous lichen planus

Abstract

This chapter focuses on vesiculobullous disorders and presents images of subcorneal-intraepidermal blisters, suprabasal blisters, subepidermal blisters with minimum inflammation, subepidermal blisters with eosinophils, and subepidermal blisters with neutrophils. Acantholysis is not prominent, and grampositive cocci can be demonstrated in impetigo in contrast to pemphigus foliaceus. Histopathological findings in pemphigus erythematosus are similar to pemphigus foliaceus. Spongiform pustules and mitotic figures are usually absent in subcorneal pustular dermatosis, unlike pustular psoriasis. It is difficult to differentiate drug-associated pemphigus vulgaris from idiopathic cases on histology. Acantholytic solar keratosis shows epithelial dysplasia in addition to suprabasal separation and solar elastotic changes. Bullous lichen planus will not show eosinophilic infiltrate as against lichen planus pemphigoides.

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