Chapter-03 Antibiotic Susceptibility Profiles and Initial Therapy of Isolates Pending Susceptibility Results

BOOK TITLE: Antibiotic Essentials

1. Cunha Burke A.
2. Schoch Paul E.
3. Cunha Cheston B.
4. Bottone Edward J.
5. Rex John H.
6. Silletti Rodger P.
Publishing Year
Author Affiliations
1. Winthrop-University Hospital, Mineola, New York; State University of New York, School of Medicine, Stony Brook, New York
2. Winthrop-University Hospital, Mineola, New York
3. Rhode Island Hospital and The Miriam Hospital, Alpert School of Medicine, Brown University, Providence, Rhode Island
4. Mount Sinai, School of Medicine, New York, New York, Mount Sinai School of Medicine, New York, Mount Sinai School of Medicine, New York, New York
5. University of Texas Medical School, Houston, Texas; AstraZeneca Pharmaceuticals, Macclesfield, UK
6. Winthrop-University Hospital, Mineola, New York
Chapter keywords
Antibiotic susceptibility profile, gram stain, antibiotic selection, antibiotic resistance, aerobic isolate, anaerobic isolate, empiric antibiotic therapy, sputum gram stain, urine gram stain


Antibiotic susceptibility profiles of penicillins, macrolides, tetracyclines, clindamycin, metronidazole, rifampin, TMP-SMX, and chloramphenicol; antibiotic susceptibility profiles of cephalosporins; and antibiotic susceptibility profiles of (aminoglycosides, fluoroquinolones, colistin, polymyxin B, aztreonam, tigecycline, vancomycin, quinupristin/dalf opristin, linezolid, tedizolid, daptomycin, telavancin, dalba vancin, oritavancin, nitrofurantoin, fosfomycin, and carbapenems are tabulated in this chapter which are self-explanatory. Gram stain of isolates; key factors in antibiotic selection; clinically relevant types of antibiotic resistance; clinical significance of an isolate by body site and selection of initial empiric antibiotic therapy pending susceptibility testing, aerobic isolates, capnophilic isolates, anaerobic isolates, and yeast/fungi; antibiotic mechanisms of action and resistance, empiric antibiotic therapy of selected problem pathogens; and clinical interpretation of gram stain are also covered in this chapter.

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