The aim of this chapter is to focus on the computed tomographic pulmonary angiography. Computed tomographic pulmonary angiography (CTPA) is a noninvasive diagnostic technique that employs computed tomography and a contrast agent to obtain an image of the pulmonary arteries. CTPA has evolved into one of the most useful test in diagnosing pulmonary embolism (PE). Computed tomographic pulmonary angiography is now the central investigation in suspected PE. The indication for CTPA in the pregnant patient is under discussion. In this scenario applied radiation dose is a concern. The imaging of choice depends on the initial chest radiography. Contraindications for CTPA are largely contraindications for iodinated contrast media. Iodinated contrast media may impair renal function [contrast-induced nephropathy (CIN)]. The frequency of CIN and relevance of CIN is under debate. Technical Aspects of CTPA, Imaging Findings of Pulmonary Embolism and Diagnostic Yield are covered in this chapter.