This chapter describes the drugs for the heart, which include drugs for heart failure, drugs for acute myocardial infarction, drugs for hypertension, drugs for atrial fibrillation, drugs for diabetes, and arrhythmias. Diuretic therapy remains a mainstay for the relief of distressing shortness of breath (SOB) and edema. Various drugs that are used for the management of postmyocardial infarction are beta-blockers, aspirin, clopidogrel, statins, streptokinase, and angiotensin converting enzyme inhibitors. Drugs for atrial fibrillation are digoxin, beta-blockers, warfarin, renoprotection, apixaban, dabigatran, and rivaroxaban. Digoxin remains most useful most often in combination with a small dose of a beta-blocking drug. Digoxin use is frowned upon and use has fallen drastically in the past 20 years mainly because of fear of toxicity and failure to reduce rapid rates more than 130 beats/min or on exercise.