This chapter focuses on chest X-ray interpretation. The posteroanterior chest radiograph is taken at full inspiration with a 6-feet distance between the X-ray tube and the film to minimize magnification and increase sharpness of detail, with the front of the patient’s chest pressed against the film cassette. It is important to analyze the chest film systematically, despite the temptation to focus on an obvious lesion. The routine used to ensure systematic examination varies with the individual physician. This chapter covers the normal lateral chest radiograph, abnormal signs on posteroanterior chest radiograph, abnormal signs on the lateral chest radiograph, lung parenchyma, limitations of bedside radiography, and computed tomography of the chest with radiographic correlation. Computed tomography has become the most useful imaging technique in the evaluation of chest disease after the plain chest radiograph. CT produces thin cross-sectional images of the thorax, 1–10 mm in thickness, whose contrast range can be manipulated by the operator to enhance the visualization of normal structures and lesions.