Melanoma may be not only clinically but also dermoscopically indistinguishable from benign melanocytic lesions, especially in early stages. The overlap of dermoscopic criteria for melanoma and atypical nevi may lead to overlook melanomas and to excise a large number of benign lesions. The use of sequential dermoscopy images allows for an objective comparative analysis, which helps in the identification of subtle changes, otherwise not visible, adding useful information for the differentiation of early melanomas from benign melanocytic lesions. The follow-up examinations include two steps: the first step is body mapping, for comparison of total-body images with previous registries to detect any changes in shape, color, or surface eventually occurring in any pigmented skin lesions, and for identification of new lesions; and the second step is sequential digital dermoscopy, for the dermoscopic comparison and storage of lesions with atypical features, and for the clinical and dermoscopic examinations of eventual new lesions not previously registered.