The objective of this chapter is to describe about pain relief in labor. Labor pain is unique compared with other forms of acute pain. It has a very wide range of severity; hence, views about the need for its relief are very diverse. Even the extreme pain of labor is often forgotten after the baby’s arrival, leaving behind a vivid memory of the side effects of the method of pain relief. Pain relief in labor is provided to minimize the deleterious effects of stress on the mother and the baby. There are various methods of pain relief, the choice among which is influenced by—first, the availability, at the place of delivery, of both the method itself and staff appropriately skilled in its use; second, the wishes of the mother, which are conditioned by the information given to her during preparation for childbirth; third, any pre-existing medical condition; and finally, and perhaps most importantly, the nature of the obstetric process and the intervention. Nitrous oxide, systemic analgesics, epidural analgesia, caudal analgesia, spinal analgesia and new trends in epidural drugs and techniques are also discussed in this chapter.