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Chapter-17 Drug-induced Liver Injury

BOOK TITLE: Liver Biopsy Made Easy

Author
1. Bihari Chhagan
ISBN
9789386150264
DOI
10.5005/jp/books/14215_18
Edition
1/e
Publishing Year
2018
Pages
18
Author Affiliations
1. Institute of Liver and Biliary Sciences, New Delhi, India
Chapter keywords
Drug-induced liver injury, DILI, chronic liver disease, acute liver failure, ALF, hepatic failure, subclinical liver injury, intrinsic DILI, idiosyncratic DILI

Abstract

A liver injury induced by a drug or herbal medicine resulting in liver test abnormalities or liver dysfunction with a reasonable exclusion of other potential etiologies and it can manifest as acute, acute on chronic or chronic liver disease. Importance of drug-induced liver injury, clinical sign and symptoms, risk factors for drug-induced liver injury, indications of liver biopsy in DILI, role of liver histopathology, morphological patterns of DILI in liver histopathology, frequency of types of liver injury, pathomorphology of DILI, and liver histology and outcome in DILI.

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