This chapter provides appropriate detail about the albumin and Rho(D) immunoglobulin. Nausea, vomiting, headache, fluid overload, hypertension, tachycardia, fever and chills are common side effects of albumin. Serious one is pulmonary edema. Nausea, vomiting, diarrhea, headache, hypertension, rash, anemia, fever and arthralgia are common side effects of Rho(D) immunoglobulin. Action, uses, dosage, brands, side effects and nursing consideration of albumin and Rho(D) immunoglobulin are also discussed throughout in this chapter.