Amputee-related pain is categorized into postoperative, incisional, phantom, and persistent residual limb pain. Evaluation of amputee pain includes location, character, frequency, duration, and intensity of the pain. Treatments include oral medications, physical modalities, prosthetic modification, procedural and surgical interventions. Prosthetic appliances and support services play a dynamic role in management of amputee pain. These include facilitating wound healing, controlling postoperative pain, restoring prior function, and managing persistent residual limb pain. This chapter covers the postoperative and phantom pain, intrinsic residual limb pain, and extrinsic residual limb pain.