Intravenous infusion therapy is an effective treatment for pain syndromes such as fibromyalgia, neuropathic pain, phantom limb pain, and complex regional pain syndrome. Intravenous infusions are not a primary method for analgesia, but are adjunct therapy to minimize the severity of debilitating chronic pain states. There are currently no universal guidelines in place for intravenous (IV) infusions for chronic pain. Lidocaine was the first amino-amide local anesthetic discovered and was first isolated by Nils Lofgren in 1943. Ketamine is indicated for complex regional pain syndrome, fibromyalgia, ischemic pain, neuropathic pain, phantom limb pain and postherpetic neuralgia. Developed in 1962, ketamine gained widespread use during the Vietnam War as a battlefield anesthetic because of its short half-life and hemodynamic stability.