This chapter provides detail about provocation discography. Provocation discography is a useful tool in determining whether the source of a patient’s pain is the intervertebral disc. Provocation discography may also accelerate disc degeneration and should be performed only when the need for information is weighed carefully. As the intervertebral disc ages, degeneration can lead to height loss and fissuring of the annulus fibrosis. Height loss does not necessarily directly cause pain, however, the annular tears allow for nociceptive nerve ingrowth that responds to inflammatory cytokines. This is a suggested etiology of discogenic pain. The goal is to stimulate the disc by increasing the intervertebral disc pressure and reproducing the patient\'s pain. It can be done in the cervical, thoracic, or lumbar discs, with the latter being the most common.