The epidural space is a central axis target point for the administration of agents for analgesic purposes. It is an oval conduit composed of various tissues: blood vessels, lymphatic structures, and fat. The epidural space spans cranially from the foramen magnum to the sacral hiatus distally. The boundaries of the posterior epidural space are the dura mater ventrally and just past the laminar shelf of the vertebra, and the ligamentum flavum dorsally. Uptake of agents occurs via fat and vascular uptake, with some agent diffusing through the dura and nerve roots, accounting for a dual systemic and local mechanism of analgesia. Evaluation and management steps are discussed with the help of a well-colored figure.