This chapter discusses palliative care, which includes Hospice palliative care and supportive palliative care. Hospice is a care model that provides palliative care to terminally ill patients and supporting services to the patients and their families, 24 hours-a-day both at home and inpatient settings. The hospice is responsible for payment for all treatments, including invasive interventions such as radiation therapy, palliative chemotherapy, etc. Supportive palliative care emphasis is on patient-centered symptom control provided by an interdisciplinary care team, treating the patient/family as a unit of care, and may be appropriate at any stage of a serious illness in a variety of settings. The goals of supportive palliative care are to relieve suffering and improve the quality of life by preventing, reducing, and relieving the symptoms of disease or a disorder without effecting a cure, even while running parallel to curative efforts.