The chapter basically talks about the lumbosacral radiculopathy. Lumbosacral radiculopathy originates secondary to either compression or impingement of a nerve root either at the level of the foramen or the lateral recess during its course from the spinal cord to its associated area of distribution. Due to this nerve impingement and its resultant inflammation, this insult to the nerve may progress to the point where it causes neurological symptoms such as numbness and weakness along the dermatomal distribution of the nerve. Radicular pain specifically describes the pain component that can emanate from a specific spinal nerve root along its distribution, independent of the existence of a radiculopathy. Nerves can be compromised by many sources such as surrounding bones, muscles, cartilage, or herniated discs that can eventually result in an inflammatory process leading to a multitude of symptoms. Etiology, clinical considerations, and treatment options are also provided in this chapter.