This chapter discusses on acute pharyngitis, otitis media and mastoiditis. Acute pharyngitis is one of the more common childhood infections and can also occur in adults. Infection with this pathogen is also causally linked to potentially serious nonsuppurative complications such as the development of rheumatic fever/rheumatic heart disease (RF/RHD) and acute poststreptococcal glomerulonephritis (PSGN). Laboratory confirmation by throat swab culture for GAS pharyngitis is recommended for children because pharyngitis and tonsillitis may result from various etiologies other than GAS infection. Acute otitis media (AOM) is the second-most common disease of childhood, after upper respiratory infection. It is also the most common cause of childhood visits to an ER, OPD and private practitioners\' clinics. Amoxicillin remains the first-line drug of choice, even in this era of increased pneumococcal resistance. Common indications for changing antibiotic therapy during treatment of AOM are also listed in this chapter. Antimicrobial prophylaxis for recurrent otitis media is also discussed in this chapter.