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Chapter-12 Mycobacterium Tuberculosis Infection

BOOK TITLE: Concise Handbook of Infectious Diseases

Author
1. Sahadulla MI
ISBN
9789386261939
DOI
10.5005/jp/books/14120_13
Edition
1/e
Publishing Year
2018
Pages
5
Author Affiliations
1. Kerala Institute of Medical Sciences (KIMS) Healthcare Group, Thiruvananthapuram, Kerala, India
Chapter keywords
Tuberculosis, TB, Mycobacterium tuberculosis, acid-fast bacterium, AFB, latent TB infection, LTBI, clinical manifestation, diagnostic testing, microbiologic test

Abstract

Tuberculosis (TB) is a global human disease caused by Mycobacterium tuberculosis complex (MTBC), a group of closely related, acid-fast bacterium (AFB) that routinely includes the human pathogens M. tuberculosis, M. bovis, and M. africanum. The natural history of TB begins with the inhalation of MTB organisms. A period of bacterial replication and dissemination ensues, followed by immunologic containment of viable bacilli. The result of this process is asymptomatic latent TB infection (LTBI), which is defined as a state of persistent bacterial viability, immune control and no evidence of clinically manifested active tuberculosis. This chapter aims to cover a discussion on clinical manifestations, diagnostic testing, and culture and other microbiologic tests for M. tuberculosis infection.

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