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Chapter-12 Mycobacterium Tuberculosis Infection

BOOK TITLE: Concise Handbook of Infectious Diseases

Author
1. Sahadulla MI
ISBN
9789386261939
DOI
10.5005/jp/books/14120_13
Edition
1/e
Publishing Year
2018
Pages
5
Author Affiliations
1. Kerala Institute of Medical Sciences (KIMS) Healthcare Group, Thiruvananthapuram, Kerala, India, Kerala Institute of Medical Sciences (KIMS), Health Care Group, Thiruvananthapuram, Kerala, India
Chapter keywords
Tuberculosis, TB, Mycobacterium tuberculosis, acid-fast bacterium, AFB, latent TB infection, LTBI, clinical manifestation, diagnostic testing, microbiologic test

Abstract

Tuberculosis (TB) is a global human disease caused by Mycobacterium tuberculosis complex (MTBC), a group of closely related, acid-fast bacterium (AFB) that routinely includes the human pathogens M. tuberculosis, M. bovis, and M. africanum. The natural history of TB begins with the inhalation of MTB organisms. A period of bacterial replication and dissemination ensues, followed by immunologic containment of viable bacilli. The result of this process is asymptomatic latent TB infection (LTBI), which is defined as a state of persistent bacterial viability, immune control and no evidence of clinically manifested active tuberculosis. This chapter aims to cover a discussion on clinical manifestations, diagnostic testing, and culture and other microbiologic tests for M. tuberculosis infection.

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