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Chapter-23 Doctrine in Anti-infective Therapy and Newer Drugs

BOOK TITLE: Concise Handbook of Infectious Diseases

Author
1. Sahadulla MI
ISBN
9789386261939
DOI
10.5005/jp/books/14120_24
Edition
1/e
Publishing Year
2018
Pages
10
Author Affiliations
1. Kerala Institute of Medical Sciences (KIMS) Healthcare Group, Thiruvananthapuram, Kerala, India
Chapter keywords
Antimicrobial, newer antibacterial drug, tedizolid, daptomycin, antibiotic dosing, antimicrobial stewardship, Klebsiella pneumoniae carbapenemas, KPC, vancomycin

Abstract

This chapter seeks to familiarize the readers with doctrine in anti-infective therapy and newer drugs. Guiding principles of antimicrobials usage have been presented in this chapter. Despite a significant recent reduction in the development of new drugs, several novel concepts in the use of antibiotics have emerged. These include expanding the use of new drugs, finding new uses for old drugs, improving drug dosing, and establishing stewardship programs for more effective utilization of drugs. The most recent antibacterial agents are primarily new members of older antibiotic classes. Doripenem (imipenem) and ceftobiprole are both beta-lactam and tigecycline is a glycylcycline which is related to tetracyclines. Tedizolid is an oxazolidinone that is similar to linezolid. Tedizolid is actually a prodrug, so it is metabolized to its active moiety, and the gram-positive spectrum is its bailiwick. A detailed description on antibiotic dosing and antimicrobial stewardship is also provided in this chapter.

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