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Chapter-07 Bacterial Sepsis/Meningitis: Targeted, Empiric and Specific Antibiotics

BOOK TITLE: Concise Handbook of Infectious Diseases

Author
1. Sahadulla MI
ISBN
9789386261939
DOI
10.5005/jp/books/14120_8
Edition
1/e
Publishing Year
2018
Pages
9
Author Affiliations
1. Kerala Institute of Medical Sciences (KIMS) Healthcare Group, Thiruvananthapuram, Kerala, India
Chapter keywords
Sepsis, meningitis, septic shock, nervous system infection, antimicrobial susceptibility test, AST, lumbar puncture, cerebrospinal fluid, empiric antimicrobial therapy

Abstract

The objective of this chapter is to cover a discussion on targeted, empiric, and specific antibiotics for bacterial sepsis/meningitis. The clinical presentation of sepsis is highly variable depending on the etiology and age. Immediate blood cultures and cerebrospinal fluid (CSF) culture is recommended unless lumbar puncture (LP) is contraindicated. Causes of bacterial sepsis/meningitis in immunologically normal children and adults are tabulated in this chapter. The definition of severe sepsis and septic shock in children is similar to that in adults. However, in pediatric patients, a systemic inflammatory response includes abnormal temperature and abnormal leukocyte count as part of clinical presentation. General considerations that guide clinicians in selecting and initiating antimicrobial regimens are presented in this chapter.

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