Skin infections are not infrequent in our clinical practices and are also an important target for antimicrobial stewardship interventions such as overuse of broad-spectrum drugs, including double coverage and prolonged duration. Streptococci particularly Staphylococcus aureus and group A beta hemolytic streptococci (GABHS) are the most common bacteria causing skin infections of clinical importance erysipelas, cellulitis, subcutaneous abscess, necrotizing fasciitis (NF). S. aureus causes a variety of localized and invasive suppurative infections and three toxin-mediated syndromes i.e. toxic shock syndrome (TSS), scalded skin syndrome (SSS), and food poisoning. CA-MRSA most often causes purulent SSTIs (skin and soft tissue infections) and, less often, pneumonia. NF is an SSTI that extends beyond the epidermis, dermis and subcutaneous fat tissue to involve the fascia and potential underlying muscles. TSS is an uncommon and potentially fatal infection caused by toxin-producing Staphylococci and Streptococci.