Bringing pharmacogenomics and personalized medicine into clinical practice

JOURNAL TITLE: Annals of SBV

Author
1. C. Adithan
ISSN
2395-1982
DOI
10.5005/jp-journals-10085-5103
Volume
5
Issue
1
Publishing Year
2016
Pages
5
Author Affiliations
    1. Central Inter-Disciplinary Research Facility Sri Balaji Vidyapeeth Mahatma Gandhi Medical College and Research Institute Campus Pillaiyarkuppam, Puducherry - 607403, India
  • Article keywords
    Pharmacogenomics, Personalized medicine, Genetic testing, Drug toxicity

    Abstract

    Pharmacogenomics and personalised medicine are emerging as important tools in individualised drug therapy. Many of the genes which encode drug metabolising enzymes, transporters and receptors are polymorphic. Individuals with polymorphic genes are likely to experience therapeutic failure or drug toxicity. This is clinically important for drugs with low safety margin such as oral anticoagulants, anti-epileptics and anticancer drugs. Prior genetic testing may help to predict responders and non-responders to the above mentioned drugs, besides avoiding drug toxicity. CIDRF is planning to introduce CYP2C9, CYP2C19 and CYP2D6 genetic testing shortly, which shall help to integrate pharmacogenomics with clinical practice.

    © 2019 Jaypee Brothers Medical Publishers (P) LTD.   |   All Rights Reserved