Introduction: Diabetes mellitus is a major health disorder which is proving to be epidemic globally with alarming rate. The current study was done to find the of LH-type distribution in the patients of diabetes mellitus type-2. Methods: The samples of blood of the diagnosed cases of diabetes mellitus type-2 (n = 100) were randomly collected from the laboratory of Department of Physiotherapy, Guru Nanak Dev University, Amritsar, India. They were typed for the both ABO and LH blood groups and compared with an equal number (n = 100) of appropriate controls. Results: It was specified that patients suffering with diabetes mellitus of type-2 in comparison with the normal population considered as controls were overwhelmingly LH-negative with p-value highly significant (p <0.001) and that this was chiefly noticeable in diabetes mellitus patients with A and B blood groups. Conclusion: The persistence of hyperglycemic environment of the erythrocyte membrane in diabetes mellitus patients and saturation of the membrane receptors with glucose molecules leave less availability of receptors to get bound with the anti-LH lectin Erythrina lithosperma. So we have come to the conclusion from the results of the current study that the patients suffering from diabetes have blood group LH-negative in more individuals in comparison with the nondiabetics.