We present our experience of diagnosing the fetal persistent left superior vena cava with the absent right superior vena cava using HDlive Flow with spatiotemporal image correlation (STIC). A 28-year-old pregnant Japanese woman, gravida 2, para 1, was referred to us for routine ultrasound screening at 28 weeks and 4 days of gestation. Two-dimensional sonography and radiant flow showed a dilated coronary sinus with the four-chamber view, and revealed a blood vessel on the left side of the pulmonary artery and absence of the superior vena cava with the three-vessel view. However, there was no other cardiac anomaly. Five cardiac views by an HDlive Flow with STIC clearly showed the absence of the right superior vena cava and a persistent left superior vena cava connected to a dilated coronary sinus. HDlive Flow with STIC provides additional diagnostic clues to evaluate abnormal systemic venous return in the fetus.