Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver

JOURNAL TITLE: Euroasian journal of hepato-gastroenterology

Author
1. Agayev Rauf Maksud
2. Popandopulo Andrey Gennadiyevich
3. Jafarli Rasim Elkhan
ISSN
2231-5047
DOI
10.5005/jp-journals-10018-1107
Volume
4
Issue
2
Publishing Year
0
Pages
4
Author Affiliations
    1. Department of Surgical Disease, Azerbaijan Medical University, Baku, Azerbaijan
    1. Donetsk Institute of Emergency and Reconstructive Surgery, International Cell Culturing Center, Donetsk, Ukraine
    1. Department of Surgical Disease, Azerbaijan Medical University, Baku, Azerbaijan
  • Article keywords

    Abstract

    The efficacy of mesenchymal stem cells transplantation on regeneration activity of cirrhotic liver was evaluated in an animal model of cirrhotic liver. Autologous stem cells were obtained from bone marrow. Transplantation was performed 1 week after surgery by introducing stem cells into the liver. Immunohistochemical staining (proliferative activity, myofibroblast activation and sinusoidal capillarization) was evaluated to assess the efficacy of transplantation. It was found that, 2 months after stem cell transplantation, the severity of perisinusoidal fibrosis, inflammation of the liver and the number of myofibroblasts were reduced. Stem cell transplantation may be one of the new treatment modalities for cirrhotic liver.

    © 2019 Jaypee Brothers Medical Publishers (P) LTD.   |   All Rights Reserved