High HBcAg Expression in Hepatocytes of Chronic Hepatitis B Patients in Bangladesh

JOURNAL TITLE: Euroasian journal of hepato-gastroenterology

Author
1. Afzalun Nessa
2. Chowdhury Mohammad Shamim Kabir
3. Munira Jahan
4. Shahina Tabassum
ISSN
2231-5047
DOI
10.5005/jp-journals-10018-1036
Volume
2
Issue
2
Publishing Year
0
Pages
7
Author Affiliations
    1. Department of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
    1. Department of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
    1. Department of Virology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh
    1. Department of Medicine, Shaheed Suhrawardy Medical College and Hospital, Mirpur, Dhaka, Bangladesh
  • Article keywords

    Abstract

    The present study evaluates the intracellular expression of the hepatitis B Virus (HBV) core antigen in chronic hepatitis B (CHB) patients from Bangladesh in relation with serological, virological and histological variables. A cross-sectional study was carried out among 70 patients incidentally diagnosed as HBV chronic carriers who have undergone liver biopsy. Indirect immunofluorescence technique was used to study the intracellular expression of hepatitis B core antigen (HBcAg). The grade and cellular distribution were semiquantitatively scored according to the percentage of stained cells and their nuclear, cytoplasmic or mixed expression pattern respectively. A higher HBcAg grade was related to higher viral load, alanine aminotransferase levels and histological damage. Higher HBV DNA counts and HBcAg grade were found in hepatitis B e antigen (HBeAg)-positive patients.

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