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JOURNAL TITLE: Euroasian journal of hepato-gastroenterology
The present study evaluates the intracellular expression of the hepatitis B Virus (HBV) core antigen in chronic hepatitis B (CHB) patients from Bangladesh in relation with serological, virological and histological variables. A cross-sectional study was carried out among 70 patients incidentally diagnosed as HBV chronic carriers who have undergone liver biopsy. Indirect immunofluorescence technique was used to study the intracellular expression of hepatitis B core antigen (HBcAg). The grade and cellular distribution were semiquantitatively scored according to the percentage of stained cells and their nuclear, cytoplasmic or mixed expression pattern respectively. A higher HBcAg grade was related to higher viral load, alanine aminotransferase levels and histological damage. Higher HBV DNA counts and HBcAg grade were found in hepatitis B e antigen (HBeAg)-positive patients.
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