The basic objective of the recent analysis was to study hypertension as a risk factor for osteoarthritis (OA) knee. In this study, totally 155 patients of OA knee, of age more than 40 years, were enrolled for the study. The study was carried out in the Department of Orthopedic Surgery, King George's Medical University (KGMU), Lucknow, Uttar Pradesh, India. According to the diagnostic criteria of the American College of Rheumatology, the cases were taken into consideration. A brief history about the disease was taken, and complete examinations were done. For the clinical severity, visual analog scale (VAS) and Lequesne index were done and for radiological severity assessment, Kellgren–Lawrence (KL) grading and X-ray bilateral knee were done to observe the radiological changes. Moreover, the blood pressure was measured consecutively in both arms for three times via auscultatory method following the American Heart Association guidelines, and the average was calculated and recorded. If the recorded average is greater than 140/90 mm Hg, then the subject is labeled as “hypertensive.” In this study, we found a significant association between the severity of the OA knee and hypertension. The study is not only for our knowledge enrichment about the association of OA and hypertension, but also to fill the gaps with related information; it will reshape our knowledge toward the management of heart disease, hypertension, and OA. Also, we can determine the new possible risk factors for these diseases. How to cite this article Singh A, Verma N, Yadav M, Ali S. Analysis of Hypertension as a Risk Factor for Osteoarthritis Knee. Hypertens J 2017;3(4):167-170.